visible water retention temporary redness of face and neck weight gain headache nausea generalized weakness drug-induced hot flashes INFREQUENT side effects If experienced, these tend to have a. In clinical studies, people with liver disease had higher levels of letrozole in their body. Available for Android and iOS devices. It is created by eHealthMe based on reports of 39,784 people who have side effects when taking Letrozole from the FDA, and is updated regularly. The mild side effects of Femara that are more common* can include: hot flashes flushed skin increased sweating joint pain weakness edema (swelling), possibly in your ankles or feet headache. Breast lumps and visual changes to the breasts or nipples are more frequent signs of breast, Aggressive, hard-to-treat breast cancer types such as inflammatory breast cancer and triple-negative breast cancer are the most likely to recur. Talk to your GP or treatment team about how to manage a change in mood. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. Instead, its a type of hormone therapy. Prophylactic mastectomy is surgery to remove breast tissue. So, if your doctor prescribes letrozole for medical uses, you should not take it for other purposes such as bodybuilding or PCT. You shouldnt take letrozole while youre pregnant or breastfeeding. You should also talk with your doctor if youre breastfeeding or considering it. Learn more. Its prescribed for adult females* whove gone through menopause. To learn more, visit their websites. Abdel-Qadir, H., et al. You can unsubscribe at any time. They can recommend if theres an amount thats safe for you. Letrozole may be used with other therapies in your breast cancer treatment plan. For information about drug-condition interactions, see Other warnings in the What should be considered before taking letrozole? section below. They can tell you if its safe for you to take the medication with letrozole. If you have been given bisphosphonates (see below) as part of your treatment you will not need a scan. How many cycles of letrozole are needed to get pregnant? GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Sign up for our GoodRx Diet and Nutrition Newsletter to receive the latest healthy eating advice, recipes, and savings that are most relevant to you. [Ref], Common (1% to 10%): Urinary tract infection, urinary hesitation, urinary retention, dysuria, increased post void retention, Frequency not reported: Impotence, suppression of lactation, cystitis, aggravation of prostatic hypertrophy[Ref], Uncommon (0.1% to 1%): Fungal infection[Ref], Very common (10% or more): Application site pruritus (16.8%), Common (1% to 10%): Application site erythema, application site vesicles, application site rash, application site macules[Ref], Uncommon (0.1% to 1%): Anorexia, fluid retention[Ref], Very common (10% or more): Dizziness (up to 17%), somnolence (up to 14%), headache, drowsiness, confusion, Uncommon (0.1% to 1%): Dysphagia, convulsions, Frequency not reported: Cognitive disorders in elderly, convulsions, agitation, nightmares, anxiety, paranoia, symptoms of depression, hallucinations, asthenia, insomnia, restlessness, dependence to this drug (in patients with history of drug or substance abuse)[Ref], Common (1% to 10%): Blurred vision, dry eye, abnormal vision, Uncommon (0.1% to 1%): Angle closure glaucoma, Frequency not reported: Onset of narrow-angle glaucoma, mydriasis, intraocular hypertension, amblyopia, cycloplegia, decreased lacrimation[Ref], Frequency not reported: Falls, accidental injury[Ref], Common (1% to 10%): Insomnia, nervousness, Uncommon (0.1% to 1%): Hallucinations, confusional state, agitation, memory impairment, Frequency not reported: Psychotic disorder, anxiety, nightmares, paranoia, abnormal behavior[Ref], Common (1% to 10%): Cough, oropharyngeal pain, dry throat, nasal dryness, Uncommon (0.1% to 1%): Upper respiratory tract infection, rhinitis, chest discomfort, hoarseness, Rare (0.01% to 0.1%): Nasal congestion, throat irritation[Ref]. The study uses data from the FDA. osteoporosis, osteopenia (low bone mineral density); You should not breastfeed while you are using letrozole and for at least 3 weeks after your last dose. contain a code you can scan with a smartphone to change the text to audio. Their risk is higher because of the cancer itself and some treatments for breast cancer. Hormones are substances produced naturally in the body. Alcohol isnt known to interact with letrozole. They work by reducing the amount of the hormone estrogen in your body. Along with its needed effects, oxybutynin (the active ingredient contained in Oxytrol) may cause some unwanted effects. Even if you transfer Candida onto another person, they likely won't develop a yeast infection unless they are already prone to the condition. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Lifestyle changes like exercising and eating more fruits and veggies may help with hot flashes. A burning feeling when you pee. They can suggest ways to help you manage a body weight thats healthy for you. In fact, this was a common side effect in studies of letrozole. You may have some side effects very quickly. By taking proactive steps, like healthy eating and exercise, you may be able to prevent or manage weight gain from letrozole. So, blocking the actions of aromatase lowers estrogen levels in postmenopausal women. Dizziness Letrozole may cause dizziness. Went to a urogyn who said this is a result of the tissues thinning from lack of estrogen. Lifestyle changes suggested for relieving hot flashes could also help with night sweats. Most side effects of letrozole are mild and temporary, lasting only a few days or weeks until your body gets used to taking the medication. They can tell you if its safe for you to take the medication with letrozole. As mentioned above, low estrogen levels can lead to bone loss. If you're having trouble, your doctor may prescribe a drug called letrozole. Letrozole. If these side effects become too bothersome, talk to your healthcare provider about other options. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Yes FDA label information for this drug is available at DailyMed. Heres a short list of some of the mild side effects that letrozole oral tablets can cause. If you have concerns about eating certain foods with letrozole, talk with your doctor. Everyone reacts differently to drugs and some people have more side effects than others. Medically reviewed by Drugs.com on May 4, 2022. Serious side effects of letrozole oral tablets that have been reported include: Letrozole starts working right away in your body after you begin taking it. The stress of the breast cancer and the initial treatment, whether it was surgery, chemo (with steroids of course), radiotherapy or all 3 will have contributed to raised levels at the time. Letrozole can sometimes cause headaches. If you notice this or any other swelling, let your GP know. Common letrozole side effects include hot flashes and night sweats. In certain types of infertility like that caused by polycystic ovary syndrome (PCOS) an egg may not be released at the correct time, or at all. After menopause, aromatase is the main source of estrogen production. Letrozole is sometimes used off-label to treat infertility in females. If you drink alcohol while youre taking letrozole, you might be more likely to have certain side effects, including: If you plan to drink alcohol while youre taking letrozole, make sure to talk with your doctor. Costs of prescription drugs can vary depending on many factors. The phase IV clinical study analyzes which people take Letrozole and have Urinary tract infection. It is also used for women who have already had other cancer treatments (eg, tamoxifen). Note: In some cases, such as if you have severe liver problems, your doctor may prescribe a letrozole dosage of 2.5 mg every other day. You may wish to discuss this with your treatment team or GP, or ask the pharmacist who dispenses your prescriptions if they can supply you with letrozole from the manufacturer you feel suits you the best. You may develop a skin rash while taking letrozole. Keep in mind that side effects of a drug can depend on: Your doctor or pharmacist can tell you more about the potential side effects of letrozole oral tablets. Mild side effects of letrozole oral tablets that have been reported include: hot flashes feeling weak or having increased tiredness dizziness belly pain or cramping hair loss swelling, usually in. About 30% of people reported hot flashes when using letrozole for breast cancer. Letrozole and anastrozole (Arimidex) are both used to help treat certain types of breast cancer. Usually, side effects from letrozole will be reduced after the first few months of treatment. It may also cause the level of cholesterol in the blood to rise, although this doesnt usually need treatment. Relaxation exercises can also be helpful. If the bleeding continues for more than a few days, tell your specialist. If you have any side effects, whether theyre listed here or not, talk to your GP or treatment team. Follow all directions on your prescription label and read all medication guides or instruction sheets. If you want to know more about the different treatment options for infertility, talk with your doctor. Estrogen is a hormone that causes estrogen receptor-positive (ER+) breast cancer to grow. Taking it at the same time each day will help you to remember your dose. There isn't much you can do about the raised blood sugars caused by the Letrozole, and you will have to take the Letrozole for either 5 or 10 years. Store at room temperature away from moisture and heat. Legro, R. S., et al. Your breast care nurse may also be able to offer support or tell you about support services in your area. This is why chemotherapy can cause hair loss and many other side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to oxybutynin: oral solution, oral syrup, oral tablet, oral tablet extended release, transdermal film extended release, transdermal gel. When will I ovulate after taking letrozole. Using letrozole during pregnancy can be harmful to the baby. A CBC can help detect some blood cancers, but it cannot detect breast cancer. Some of these products contain plant-based estrogens, known as phytoestrogens. This is when part of the blood clot breaks away and travels to the lung. Around 6% experienced weight loss. Hot flushes can sometimes occur. You can use the study as a second opinion to make health care decisions. Like most drugs, letrozole oral tablets may cause mild or serious side effects. Before taking this medicine The phase IV clinical study analyzes which people take Letrozole and have Urinary tract infection. Find out more aboutlooking after your bones and osteoporosis . Its used to treat certain forms of: To learn more about these conditions and how letrozole treats them, see the What is letrozole used for? section below. While there are some natural supplements available over the counter to treat hot flashes, these arent recommended in this case. Letrozole can harm an unborn baby. (IUI is a procedure in which a sample of sperm is placed directly into the uterus.). These websites also offer tools to help you find low-cost healthcare and certain educational resources. 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